Oysho started in September 2001, when Oysho opened its first 10 stores in Spain and Portugal. By the end of the year, the number reaches 27 stores. At this time, the brand already operates in 4 European countries: Spain, Portugal, Italy and Greece. In 2007 Oysho opened the market in Serbia, Russia, Romania, Qatar, Oman, Jordan, Hungary, France, Cyprus, Bahrain and Andorra, reaching 22 countries, including Mexico, Kuwait and the United Arab Emirates.

In 2011, Oysho celebrated its 10th anniversary and established itself as a brand by opening new and important markets in China, Egypt, the Dominican Republic, Guatemala, Morocco and Ukraine. Oysho carries out the redesign / restyling of the logo and, in September of the same year, opens its online sales website.

In 2012 the chain's new logistics center was inaugurated, located in Tordera (Barcelona) Spain with a 51,736m2 warehouse.

In 2015, the chain launched an online marketplace in China together with the Chinese e-commerce giant Alibaba and subsequently its online store.